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KMID : 0370220010450060677
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Yakhak Hoeji
2001 Volume.45 No. 6 p.677 ~ p.682
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Effect of Ethanol on Histamine Release from Rat Peritoneal Mast Cells
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김창종/Kim CJ
이윤혜/이승준/서무현/장용운/심상수/Lee YH/Lee SJ/Seo MH/Jang YU/Sim SS
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Abstract
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To investigate action of ethanol on histamine release from rat peritoneal mast cells, we compared the inhibitory effect of ethanol with those of calcium antagonists in mechanism of between ATP and compound 48/80-induced histamine release. Ethanol dose-dependently inhibited 100μM ATP-induced histamine release, whereas did not inhibit 1 ㎍/ml compound 48/80-induced histamine release. Verapamil, TMB-8 and EGTA dose-dependently inhibited ATP-induced histamine release, but did not inhibit compound 48/80-induced histamine release. Such an inhibitory effect of calcium antagonist was similar to that of ethanol. These results suggest that the inhibitory effect of ethanol on histamine release from rat peritoneal mast cells is mediated via disturbance of calcium mobilization.
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KEYWORD
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